Guest:

Dr. Jonathan Kipnis is the BJC Investigator and Alan A. and Edith L. Wolff Distinguished Professor of Pathology and Immunology at Washington University in St. Louis. His lab investigates the complex interactions between the immune and nervous systems. He talks about immune activity and surveillance in the brain, and how T cell subsets affect brain function and behavior. He also discusses the brain’s immune reservoir and his lab’s work on cerebrospinal fluid-regulated immune cell mobilization.

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The Immunology Science Round Up

Intranasal Vaccines for HIV and SARS-CoV-2 – Researchers developed vaccines that use the neonatal Fc receptor to mediate transmucosal uptake and elicit immune responses at both local and distal mucosal sites.

How ADAR1 Mutation Leads to Autoimmune Responses – Scientists found that ZBP1-dependent signaling underlies the autoinflammatory pathology caused by the alteration of ADAR1.

Preventing Autoinflammation – Researchers identified ADAR1 as a negative regulator of ZPB1-mediated apoptosis and necroptosis, providing insights into the pathology of Aicardi–Goutières syndrome.

Averting Interferon Induction – ZBP1 promotes type I interferon activation and fatal pathology in mice with impaired ADAR1 function.

The Interleukin-17 Ligand-Receptor Axis – Scientists explored the explore the structural basis for interleukin-17 family signaling.

Image courtesy of Dr. Jonathan Kipnis