Guest:

Dr. Michael Rosenblum is a Professor of Dermatology at the University of California, San Francisco. His lab seeks to to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. They are currently investigating how regulatory T cells (Tregs) control immune responses in tissues, as well as their “alternative” functions. He talks about early-life inflammation and type 2 helper T cells in the skin, and how Tregs can be manipulated to target autoimmune diseases and cancer.

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The Immunology Science Round Up

Tissue-Resident Memory T Cells in the Brain – After viral brain infection, tissue-resident memory T cells triggered central nervous system inflammation, promoting autoimmune reactions in mice.

Suppressing HIV with Antibodies – Anti-HIV-1 antibodies can maintain viral suppression and may accelerate viral reservoir decay.

Enhancing Hepatitis B Therapeutic Vaccine Responses – Natural killer cell depletion enhanced T cell responses to a chimp adenoviral vectored hepatitis B virus.

CAR T Cell Cytotoxicity in Glioblastoma – Researchers found that interferon gamma signaling is crucial for proper engagement and killing of solid tumors by CAR T cells.

Image courtesy of Dr. Michael Rosenblum