Guest:

Dr. Jenny Ting is the William R. Kenan Jr. Distinguished Professor of Genetics at the University of North Carolina at Chapel Hill, and served as the President of the American Association of Immunologists from 2020-2021. Her lab discovered the NLR protein family, and their recent research interests include oxidative phosphorylation in HIV, the role of AIM2 in autoimmunity, and microbes that can protect from radiation.

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The Immunology Science Round Up

Replication Stress Response Defects in Cancer – Replication stress response defects led to single-stranded DNA accumulation in cancer cells and improved responses to immune checkpoint blockade.

Responses to Immune Checkpoint Inhibition in Renal Cell Carcinoma – Researchers identified baseline pre-treatment T cell receptor clonality as a predictor of immunotherapy response in renal cell carcinoma.

DNA Methylation Signatures of Immune Cells – Scientists found that adaptive and innate immune cells show distinct methylation and gene expression patterns.

Comparing SARS-CoV-2 Variants – The Delta variant spike protein can fuse membranes more efficiently at low levels of cellular receptor ACE2 compared to other variants. Learn more about SARS-CoV-2 entry into cells in this review.

Image courtesy of Dr. Jenny Ting