Dr. Mark Shlomchik is a UPMC Endowed Distinguished Professor and Chair of the Department of Immunology at the University of Pittsburgh. He is also a Founder and Chief Scientific Officer of BlueSphere Bio, a company working to create individualized T cell therapies for the treatment of cancer. Dr. Shlomchik’s lab focuses on systemic autoimmune diseases, long-lived B cell immunity, and immunopathogenesis. He talks about the role of toll-like receptors in lupus, how his autoimmune disease research led to potential cancer therapies, and starting a biotech company with his brother.
Dr. Alice Long is an Associate Member of the Center for Translational Immunology at Benaroya Research Institute at Virginia Mason. The Long lab is focused on understanding how tolerance is lost in autoimmunity, specifically as it related to type 1 diabetes. Dr. Long discusses the work she presented at the American Association of Immunologists’ annual meeting, IMMUNOLOGY2022, on CD8 T cell exhaustion and Treg modulation.
Dr. Michael Rosenblum is a Professor of Dermatology at the University of California, San Francisco. His lab seeks to to understand how immune responses are regulated in tissues and how this knowledge can be exploited for therapeutic benefit. They are currently investigating how Tregs control immune responses in tissues, as well as their “alternative” functions. He talks about early-life inflammation and type 2 helper T cells in the skin, and how Tregs can be manipulated to target autoimmune diseases and cancer.
Dr. Jennifer Gommerman is a Professor of Immunology at the University of Toronto. Her team has uncovered a novel gut-brain axis that regulates neuroinflammation and is examining the role of B lymphocytes in Multiple Sclerosis (MS) patients and in animal models of MS. More recently, she has been studying the antibody response to SARS-CoV-2 in saliva samples from patients with COVID-19. She talks about the role of gut-derived plasma cells in multiple sclerosis, and how salivary immunoglobulin A can protect against breakthrough COVID-19 infections.
Dr. Jenny Ting is the William R. Kenan Jr. Distinguished Professor of Genetics at the University of North Carolina at Chapel Hill, and served as the President of the American Association of Immunologists from 2020-2021. Her lab discovered the NLR protein family, and their recent research interests include oxidative phosphorylation in HIV, the role of AIM2 in autoimmunity, and microbes that can protect from radiation.